Staff

Ai ItoSenior Assistant Professor / Ph.D.last update : 2022.12.27

Japanese

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Name: Ai Ito
Affiliation: Laboratory of Pharmaceutical Organic Chemistry
Subjects: Fundamental Organic Chemistry　
Organic Chemistry
Official title: Senior Assistant Professor
Degree: Ph.D.

Papers

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[Original paper]　Structures and Reactivities of N-Alkenyl-Substituted Anilides: The “Magic” Methyl Effect on Alkene.　Ryu Yamasaki, Mariko Ono, Kento Morita, Ai Ito, Kazuo Fukuda, Iwao Okamoto　J. Org. Chem.　88 (20)　14487–14493　2023　
[Original paper]　Synthesis and conformational analysis of N-aromatic acetamides bearing thiophene: effect of intramolecular chalcogen-chalcogen interaction on amide conformational stability.　Ai Ito, Marino Asato, Yuki Asami, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto　J. Org. Chem.　88 (11)　7075–7087　2023　
[Original paper]　Structure and Additive-free Transamidation of Planar N-Cyano Amides.　Ryu Yamasaki, Yuko Okada, Hiromi Iizumi, Ai Ito, Kazuo Fukuda, Iwao Okamoto　J. Org. Chem.　88 (9)　5704–5712　2023　
[Original paper] 　Reversible On/Off Conformational Switching of Pentafluorobenzoyl Amide Triggered by Acid Vapor and Sublimation　Ryu Yamasaki, Misuzu Harada, Ai Ito, Kazuo Fukuda, Shota Matsumoto, Satoru Karasawa, Iwao Okamoto　CrystEngComm　24 (35)　6226–6231　2022　
[Original paper] 　Conformational Switch of Benzanilide Derivative Induced by Acid; Effect of Pentafluorobenzoyl Group　Ryu Yamasaki, Misuzu Harada, Rino Nagata, Ai Ito, Kazuo Fukuda, Iwao Okamoto　The Journal of Organic Chemistry　87 (13)　8469–8479　2022　
[Original paper]　Synthesis of Probe Molecules, 6-(Dimethylamino)-2-phenylisoindolin-1-ones, for Mechanistic Studies of Firefly Luciferase Inhibition　Medha J. Gunaratna, Bo Hao, Man Zhang, Madoka Nakagomi, Ai Ito, Takeo Iwamoto, Duy H. Hua　Heterocycles　103 (1)　231-248　2021　
[Original paper]　Synthesis and crystal structures of N,N-diarylacetamides bearing two azulene rings　Ai Ito, Mayuko Watanabe, Ayako Ishii, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Letters　86　Article 153523　2021　
[Original paper] 　Synthesis and conformational analysis of N-aryl-N-(6-azulenyl)acetamides　Ai Ito, Ayako Ishii, Takamasa Amaki, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Lett.　　60 (29)　1929-1933　2019　
[Original paper] 　N-Ethynylation of Anilides Decreases the Double-Bond Character of Amide Bond while Retaining trans-Conformation and Planarity　Ryu Yamasaki, Kento Morita, Hiromi Iizumi, Ai Ito, Kazuo Fukuda, Iwao Okamoto　Chem. Eur. J.　25 (43)　10118-10122　2019　
[Original paper] 　Conformational analysis of N-aryl-N-(2-azulenyl)acetamides　Ai Ito, Takamasa Amaki, Ayako Ishii, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Lett.　59 (45)　3994-3998　2018　
[Original paper] 　Spontaneous and direct transformation of O-aryl-N-aryl carbamates into N,N'-diarylureas　Ryu Yamasaki, Yutaka Honjo, Ai Ito, Kazuo Fukuda, Iwao Okamoto　Chem. Pharm. Bull.　66 (9)　880-884　2018　
[Original paper] 　Synthesis and conformational analysis of N-aryl-N-(3-thienyl) acetamides　Ai Ito, Yuki Asami, Marino Asato, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Lett.　59 (25)　2454–2458　2018　
[Original paper] 　Crystal engineering of N,N'-diphenylurea compounds featuring phenyl-perfluorophenyl interaction　　Ryu Yamasaki, Mana Iida, Ai Ito, Kazuo Fukuda, Aya Tanatani, Hiroyuki Kagechika, Hyuma Masu, Iwao Okamoto　Cryst. Crowth Des.　17 (11)　5858–5866　2017　
[Original paper] 　Acid-controlled switching of conformational preference of N,N,-diarylamides bearing pyridine.　Ai Ito, Hiroto Fujino, Keiko Ushiyama, Eriko Yamanaka, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Lett.　57 (42)　4737-4741　2016　
[Original paper]　Acid-induced molecular-structural transformation of Ｎ-methyl aromatic oligoamides bearing pyridine-2-carboxamide　Ryu Yamasaki, Saori Fujikake, Ai Ito, Kentaro Migita, Nobuyoshi Morita, Osamu Tamura, and Iwao Okamoto　Tetrahedron Lett.　57(1)　56-59　2016　
[Original paper]　Acid- and base-induced conformational alternations of Ｎ-aryl-Ｎ-troponyl amides　Ai Ito, Masanori Sato, Ryu Yamasaki, and Iwao Okamoto　 Tetrahedron Lett.　57(3)　438-441　2016　
[Original paper]　Silicon-Containing GABA Derivatives, Silagaba Compounds, as Orally Effective Agents for Treating Neuropathic Pain without Central-Nervous-System-Related Side Effects　Hiroshi Fukasawa, Hideaki Muratake, Ai Ito, Hideyuki Suzuki, Yohei Amano, Marina Nagae, Kiyoshi Sugiyama and Koichi Shudo　ACS Chem Neurosci.　5(7)　525-532　2014　
[Original paper]　Deprotonation Equilibrium of 5-Tropolonediazonium Salt Strongly Favors 1,2,5-Tropoquinone-5-diazide Structure in Certain Solvents.　Ai Ito, Hideaki Muratake, and Koichi Shudo　J. Org. Chem.　78(11)　5470-5475　2013　
[Original paper]　A Novel Aromatic Carboxylic Acid Inactivates Luciferase by Acylation of an Enzymatically Active Regulatory Lysine Residue.　Madoka Nakagomi, Nobuko Fujimaki, Ai Ito, Takahiro Toda, Hiroshi Fukasawa, Koichi Shudo, Ryoichi Tomita 　PLoS